[Skip to Navigation]
April 1975

Methysergide in the Treatment of Narcolepsy

Author Affiliations

From the Department of Neurological Surgery and Division of Electroencephalography and Clinical Neurophysiology, University of Washington School of Medicine, Seattle.

Arch Neurol. 1975;32(4):265-268. doi:10.1001/archneur.1975.00490460081012

Five patients with narcolepsy (four with the allied symptom of cataplexy) were treated with the serotonin antagonist methysergide. All patients had as good control of their sleep attacks while on methysergide therapy as on a control period of dextroamphetamine therapy. The cataplexy was less well controlled by methysergide than by dextroamphetamine, but improved when compared to a period without medication. Two patients developed severe calf claudication while on methysergide.

Add or change institution