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May 1975

Neurotoxicity of Topically Applied Hexachlorophene in the Young Rat

Author Affiliations

From the Laboratory of Neuropathology, Department of Pathology, University of Washington School of Medicine, Seattle.

Arch Neurol. 1975;32(5):315-319. doi:10.1001/archneur.1975.00490470059008

Young rats 6 to 22 days of age are extremely susceptible to the neurotoxic effects of hexachlorophene given as a daily bath of undiluted antiseptic detergent containing 3% hexachlorophene (pHiso-Hex). At this age, most rats are clinically and histologically damaged by as few as two daily baths. Younger rats are relatively resistant, probably because they have less myelin to be affected; older rats cannot be poisoned by this route, probably because the more mature liver excretes the drug more effectively.

Age-dose-response curves in rats are similar to those in humans. This experimental model is potentially useful in defining other characteristics of this drug.

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