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May 1975

Incrementing Responses in Myasthenia Gravis-Reply

Author Affiliations

Baltimore, Md

Arch Neurol. 1975;32(5):344. doi:10.1001/archneur.1975.00490470088014

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To the Editor.—  In reply to Özdemir and Young, I would make several points. The main point of the study is to show that in patients with myasthenia gravis the disorder of neuromuscular transmission is a dynamic one and that in some patients incrementing responses can be recorded at a time when the disease is progressive. No attempt was made to examine the responses in a large number of patients statistically as to sites of recording, frequency (time), depressing and augmenting factors, etc. The report also attempts to point out the value of interpreting clinical electrophysiological phenomena, such as incrementing responses, in light of experimental data, and there are many reports that patients with incrementing responses (due to botulism [Cherington and Ryan, New Engl J Med 282:195-197, 1970]; myasthenia gravis [Brown and Johns, Johns Hopkins Med J 124:1-8, 1969]; and the myasthenic syndrome [Lambert, Ann NY Acad Sci 135:367-384, 1966]

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