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June 1975

Apparent Familial Multiple Sclerosis in Three GenerationsReport of a Family With Histocompatibility Antigen Typing

Arch Neurol. 1975;32(6):414-416. doi:10.1001/archneur.1975.00490480080009

Three members of an unusual family were affected with apparent multiple sclerosis in a direct line over three successive generations. Each affected member had clinical remissions and exacerbations and evidence of lesions disseminated in space. One affected member had a cerebrospinal fluid pleocytosis and elevated γ-globulin level. The genetically determined histocompatibility antigen (HL-A) types are reported for 13 family members. The three affected members had HL-A types 11 and W16 in common.