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June 1975

Metabolic Compartmentation in the Brain

Arch Neurol. 1975;32(6):424. doi:10.1001/archneur.1975.00490480090016

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The volume is the proceedings of a symposium held in July 1971. It represents a first step toward trying to reduce biochemical studies of the brain into subfractions. The brain contains three major types of cells, neurons, glia, and vascular cells, and even among these, metabolic systems cannot be the same, otherwise one would not see such diverse susceptibilities to drugs, infectious agents, and inherited disease. It is clear in reading the volume that the biochemical studies are still largely descriptive, and have not reached the level of the elegantly detailed divisions of the cell that the electron microscopists have achieved. Nevertheless, micromethods, cell separations, tissue culture, and computer models of metabolic compartmentation offer ingenious and encouraging first steps to the analysis of a major problem in metabolic neurochemistry. These approaches are well described in the present volume, which is recommended as an introduction to what will undoubtedly become a

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