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July 1975

Multiple Sclerosis: Morphologic Evidence of Intranuclear Paramyxovirus or Altered Chromatin Fibers?

Author Affiliations

Munich, Germany; Calif

Arch Neurol. 1975;32(7):425-427. doi:10.1001/archneur.1975.00490490029001

Reports of paramyxovirus-like structures in the nuclei of mononuclear cells in lesions of acute multiple selerosis (MS) have received much attention.1-5 The studies demonstrated intranuclear electron-dense strands measuring about 18 to 22 nm in width. The isolation of a paramyxovirus from the brains of patients with MS made the impact of these observations even more pronounced.6,7 Soon, however, the pendulum began swinging in the opposite direction. Identical intranuclear strands were observed in patients with numerous other conditions, including fatal cases of tick-borne encephalitis,8 and in patients treated with anticancer drugs.9 Furthermore, no association of these intranuclear fibers with measles or parainfluenza antigen could be demonstrated by the electron microscopical immunoperoxidase technique.10 There is indeed reason to believe that the peculiar nuclear alterations do not represent viral structures but unusually preserved nucleoproteins. We wish to draw attention to the fact that the normal architecture of a

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