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August 1975

Normal Electroencephalograms in Subacute Sclerosing Panencephalitis

Author Affiliations

Dept of Pediatrics Duke Univ Med Center Durham, NC 27710

Arch Neurol. 1975;32(8):575-576. doi:10.1001/archneur.1975.00490500095015

The electroencephalogram is considered to be a reliable aid in the diagnosis of subacute sclerosing panencephalitis (SSPE),1,2 even when the clinical picture is atypical. Since measles antibodies and cerebrospinal fluid (CSF) immunoglobulin determinations are often not readily available, the EEG has assumed a role of great practical importance in the diagnosis of SSPE.

These considerations have led us to present a group of patients who initially had normal EEGs, often when SSPE was moderately advanced.

Patients and Methods.—  Eleven new patients with SSPE were examined (Table). The diagnosis was suspected clinically and confirmed by the finding of an antimeasles titer in the CSF and/or by the demonstration of viral nudeocapsids in glial or neuronal cells in brain tissue.All EEGs were recorded by encephalographs with surface scalp electrodes employing the in ternational 10-20 system of electrode placement and a variety of bipolar and reference montages. In the majority of

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