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September 1975

APO Low Density Lipoprotein Localization: Intracranial and Extracranial Atherosclerotic Lesions From Human Normolipoproteinemics and Hyperlipoproteinemics

Author Affiliations

From the Baylor-Methodist Center for Cerebrovascular Research, the departments of Neurology and Pathology, Baylor College of Medi-; cine and the Methodist Hospital, Houston.

Arch Neurol. 1975;32(9):600-605. doi:10.1001/archneur.1975.00490510056003

• APO low density lipoprotein (apoB), the major protein in plasma low (LDL) and very low (VLDL) density lipoproteins, was localized in extracranial and intracranial arteries from normolipoproteinemics and hyperlipoproteinemics to determine if apoB extensiveness and localization varied with plasma lipoprotein profile. Specimens of carotid bifurcation, internal carotid, basilar, and middle cerebral arteries from 23 subjects with normal lipoprotein levels, four with elevated LDL (type II), and 13 with elevated VLDL (type IV) values were studied with the employment of immunofluorescence techniques. Although the apoB localization pattern was identical in each group, extensiveness of positive localization was greatest in lesions from type II cases and the same in lesions from type IV and normolipoproteinemics. This suggests that sites of apoB retention are dependent on the chemical and structural changes in atherosclerotic arteries, whereas extensiveness correlates with the apoB concentration gradient between plasma and tissue.

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