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Article
October 1975

Congenital Ichthyosis With Spastic Paraplegia of Adult Onset

Arch Neurol. 1975;32(10):699-701. doi:10.1001/archneur.1975.00490520069011
Abstract

• Two siblings had what we believe to be a unique disorder manifested by stationary congenital ichthyosiform erythroderma coupled with a slowly progressive spastic weakness of adult onset. The disorder was presumably inherited as an autosomal recessive trait. The mechanism by which a genetic mutation would mediate this multiple organ system disorder is unknown.

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