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Article
October 1975

Serotonin Metabolism in Pellagra

Author Affiliations

From the National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.

Arch Neurol. 1975;32(10):708-710. doi:10.1001/archneur.1975.00490520078015
Abstract

• Altered mental status is common in pellagrins. We evaluated the mental status of pellagrins in relation to the neurohormone, serotonin or 5-hydroxytryptamine (5-HT). Levels of 5-hydroxyindoleacetic acid (5-HIAA), an end product of serotonin in the urine and cerebrospinal fluid (CSF), and of platelet 5-HT were determined in a group of pellagrins and in normal subjects. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The 5-HIAA concentration in CSF was also reduced, suggesting a decrease in 5-HT functional activity in the brain.

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