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October 1975

End-Plate Morphology in Amyotrophic Lateral Sclerosis

Author Affiliations

From the Institutes of Medical Sciences, Pacific Medical Center, San Francisco.

Arch Neurol. 1975;32(10):711-712. doi:10.1001/archneur.1975.00490520081016

• Intercostal muscle end-plates were measured in patients with amyotrophic lateral sclerosis (ALS) and more benign motor neuron disease (MND). The length of the intact end-plates in ALS and MND was not different from the controls. Segmented end-plates were increased in both ALS and benign MND, and the end-plate length was greatest in ALS. In individual ALS cases, no correlation was found between the end-plate abnormalities and relevant clinical variables.

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