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January 1976

Triethyltin Sulfate-Induced Neuropathy in Rats: Electrophysiologic, Morphologic, and Biochemical Studies

Author Affiliations

From the departments of pathology (division of neuropathology) (Drs Graham and Gonatas) and neurology (Drs de Jesus and Pleasure), University of Pennsylvania School of Medicine, Philadelphia. Dr Graham is now at Southern General Hospital, Glasgow, Scotland.

Arch Neurol. 1976;33(1):40-48. doi:10.1001/archneur.1976.00500010042007

• Adult rats given high orally administered doses of triethyltin (TET) sulfate lost weight, developed hind limb wasting, and became paraplegic or quadriplegic within three weeks of intoxication. A 33% reduction in the motor nerve conduction velocity (MNCV) of the sciatic nerve in the absence of significant demyelination was observed. There was observed, however, intramyelinic edema formation and an increased number of axonal neurofilaments and neurotubules; changes that paralleled the decrease in MNCV during the period of intoxication. Although the animals became asymptomatic and the MNCV normalized within two to three weeks of discontinuing the TET intoxication, the intramyelinic vacuoles and the increased numbers of neurofilaments and neurotubules persisted.

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