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February 1976

Hemiplegic Amyotrophy: Muscle and Motor Point Biopsy Study

Author Affiliations

From the Neurology Service and Neurology Research Laboratory, Veterans Administration Hospital, Hines, Ill (Drs. Chokroverty and Rubino), and the departments of neurology, The Chicago Medical School (Dr Chokroverty), the Mount Sinai Hospital Medical Center, Chicago (Drs Chokroverty and Reyes), and Albany (NY) Medical College (Dr Barron).

Arch Neurol. 1976;33(2):104-110. doi:10.1001/archneur.1976.00500020032006

• Thirty hemiplegic patients had simple muscle atrophy with reduced mean muscle cross sectional areas (predominantly type II fiber atrophy) and complex, multiple, or enlarged subneural apparatuses, many of which resembled subhuman end-plates. Ultrastructural observations in a few patients revealed nonspecific responses of damage to sarcolemma and myofibrils. There was no correlation between structural changes and alteration of tone, sensory impairment, or site of lesion. We propose that hemiplegic amyotrophy results from a combination of disuse, loss of central "trophic" influence, and transsynaptic degeneration.

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