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February 1976

Modification of the Actions of Some Neuroactive Drugs by Growth Hormone

Author Affiliations

From the Medical Research Center, Brook-haven National Laboratory, Upton, Long Island, NY. Dr Cotzias is now with the Department of Neurology, Cornell Medical Center, New York.

Arch Neurol. 1976;33(2):131-134. doi:10.1001/archneur.1976.00500020059009

• The flat serum growth hormone (GH) patterns of untreated parkinsonian patients develop diurnal rises during treatment with levodopa. This chronic exposure to excesses of GH might lead to the eventual emergence of the "on-off" phenomenon, which would indicate a need for animal experiments. Pretreatment of mice with GH increased (1) cerebral dopa and dopamine concentrations in levodopa-treated mice, (2) cerebral accumulation of injected tritiated apomorphine and tritiated thymidine, and (3) behavioral responses to levodopa, L-m-tyrosine, apomorphine hydrochloride, and oxotremorine.