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April 1976

Cerebral Embolism, Marantic Endocarditis, and Cancer

Author Affiliations

From the Division of Neurology (Drs Kooiker and Sumi) and the Laboratory of Neuropathology (Dr Sumi), Department of Medicine, University of Washington School of Medicine, and the Section of Neurology, Virginia Mason Medical Center (Dr MacLean), Seattle.

Arch Neurol. 1976;33(4):260-264. doi:10.1001/archneur.1976.00500040044006

• Two subjects with cerebral embolism were found at autopsy to have marantic (nonbacterial thrombotic) endocarditis (NBTE) and an unsuspected carcinoma. An additional 16 subjects with marantic endocarditis and cancer were found on reviewing the autopsy records of 22 subjects with NBTE. Of these 18 subjects with NBTE and cancer, eight developed a stroke during their illness, in five as the initial manifestation of cancer. Although the association of cancer and marantic endocarditis is generally well recognized, cerebral embolism from this source should be more seriously considered as one of the "remote effects" of cancer on the nervous system.