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Article
April 1976

Histochemical Studies in Experimental Portal-Systemic EncephalopathyI. Glutamic Dehydrogenase

Author Affiliations

From the research and laboratory services, Verterans Administration Hospital, and the Department of Pathology, University of Colorado Medical Center, Denver.

Arch Neurol. 1976;33(4):265-269. doi:10.1001/archneur.1976.00500040049007
Abstract

• Results of a histochemical study of glutamic dehydrogenase in experimental portal-systemic encephalopathy with hyperammonemia indicate that the enzyme's activity in brain was increased in all stages of the encephalopathy, and this increase appeared to be localized exclusively in astrocytes. The results are consistent with the view that the astrocyte has a critical role in ammonia metabolism in brain, probably in ammonia detoxification. The findings, moreover, indicate that one pool of glutamate, possibly the small pool, is located in the astrocyte.

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