• Myoclonus in association with dementia of later adult life has been considered almost pathognomonic of Creutzfeldt-Jakob disease. However, myoclonus may also be seen with Alzheimer disease, and when the myoclonus occurs as an early manifestation of Alzheimer disease, distinction from Creutzfeldt-Jakob disease may prove difficult.
Faden AI, Townsend JJ. Myoclonus in Alzheimer Disease: A Confusing Sign. Arch Neurol. 1976;33(4):278–280. doi:10.1001/archneur.1976.00500040062010
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