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April 1976

Myoclonus in Alzheimer Disease: A Confusing Sign

Author Affiliations

From the Department of Neurology, University of California, San Francisco (MAJ Faden), and the Department of Neuropathology, San Francisco Veterans Administration Hospital (Dr Townsend). MAJ Faden is now with the Department of Neurophysiology, Walter Reed Army Institute of Research, Walter Reed Medical Center, Washington, DC.

Arch Neurol. 1976;33(4):278-280. doi:10.1001/archneur.1976.00500040062010

• Myoclonus in association with dementia of later adult life has been considered almost pathognomonic of Creutzfeldt-Jakob disease. However, myoclonus may also be seen with Alzheimer disease, and when the myoclonus occurs as an early manifestation of Alzheimer disease, distinction from Creutzfeldt-Jakob disease may prove difficult.

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