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April 1976

Shy-Drager Syndrome With Abnormal Respirations and Antidiuretic Hormone Release

Author Affiliations

From the Department of Neurology, University of California, San Francisco.

Arch Neurol. 1976;33(4):292-295. doi:10.1001/archneur.1976.00500040076013

• A patient with Shy-Drager syndrome exhibited a partial defect in antidiuretic hormone (ADH) release, and cluster breathing, an indication of pontomedullary respiratory center damage, with a normal CO2 response curve. This extends the spectrum of abnormalities associated with this degenerative disease of the central nervous system. The presence of a pontomedullary respiratory pattern without an impaired CO2 response curve suggests that neurons that determine respiratory rhythm function independently from those that function as chemoreceptors.

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