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April 1976

Effects of Hypotension on Rhesus Monkeys

Author Affiliations

Medical Research Council Laboratories Carshalton, Surrey, UK
Dept of Neurology Institute of Psychiatry Denmark Hill, London, S. E. 5, UK

Arch Neurol. 1976;33(4):306-307. doi:10.1001/archneur.1976.00500040090022

To the Editor.—  The article by Gamache and Myers (Arch Neurol 32:374, 1975) describing the effects of hypotension on Rhesus monkeys demands our comment not only because it makes no substantial contribution to the understanding of a clinically important type of brain damage, but also because the authors have taken the unusual step of making comparisons (in their Tables 2 and 3) between their own and "another major study."12 As we are responsible for that study, we regret that in these two tables and in several places in the text, our methods, results, and conclusions have been seriously misrepresented.The summary of the article concluded:Hypoxia and acidosis occurring during insult or recovery periods rather than hypotension itself probably account for neuropathological sequelae described by others.This statement does not apply to our own experiments for the following reasons.1. The animals (Macaca mulatta), under light pentobarbitone anesthesia breathed

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