[Skip to Navigation]
April 1976

Effects of Hypotension on Rhesus Monkeys-Reply

Author Affiliations

Laboratory of Perinatal Physiology NINCDS, Natl Institutes of Health Bethesda, MD 20014

Arch Neurol. 1976;33(4):307-308. doi:10.1001/archneur.1976.00500040091023

In Reply.—  The quote from our text should read as follows:Factors such as hypoxia and acidosis occurring during the insult and recovery periods... probably account for neuropathological sequelae described by others.A reading of Brierley and Meldrum's text reveals insufficient control of the conditions of their experiment. Their work could be titled "Brain Damage in Rhesus Monkeys Resulting From Profound Hypotension Combined With Severe Hypovolemia of Variable Duration (From 1 to 54 Minutes), Carried Out at Various Body Temperatures (From 34.1C to 38.6C), of Various Rapidities of Onset (From 2 to 44 Minutes), With the Episodes Sometimes Repeated, and With the Animals Sometimes Breathing Spontaneously, Sometimes Mechanically Ventilated, With Superimposed Alkalosis and Hypocapnea (Mean pH, 7.54 and Mean Pco2, 24 mm Hg), and With a Prolonged and Variable Rate of Restoration of Blood Pressure Afterwards." Despite variable animal treatment, the authors attribute the two pathologic outcomes (focal necrosis and diffuse

Add or change institution