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May 1976

Cerebral Protection by Barbiturate Anesthesia: Use After Middle Cerebral Artery Occlusion in Java Monkeys

Author Affiliations

From the departments of anesthesiology (Dr Michenfelder and Mr Milde) and neurosurgery (Dr Sundt), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Neurol. 1976;33(5):345-350. doi:10.1001/archneur.1976.00500050031006

• Regional cerebral ischemia was produced in 18 Java monkeys by permanent middle cerebral artery (MCA) occlusion. All monkeys were thereafter paralyzed (pancuronium bromide, 0.05 mg/kg/hr) and sedated (diazepam, 0.1 mg/kg/hr) for a 48-hour period. Thirty minutes after MCA occlusion, pentobarbital sodium anesthesia was induced in nine of the monkeys (14 mg/kg) and maintained for 48 hours (7 mg/kg every two hours), with continuous supportive care. After 48 hours, all drugs were discontinued; the monkeys were observed for five days, and then killed. Seven of the control monkeys developed a cerebral infarction, three did not survive past the 48 hours of intensive care, and the other four had a notable neurologic deficit. All pentobarbital monkeys survived the seven days, but four had a cerebral infarction and two of these had a notable neurologic deficit. These differences were statistically significant.