• Eighteen members of a family were affected over a span of five generations with the restless legs syndrome, transmitted as an autosomal dominant trait.
Ten patients had myoclonus. The propositus, a 57-year-old man, suffered from repeated, intense, asymmetric flexion jerks of the lower extremities, alternating with fidgeting and friction movements of the legs; all occurred at night prior to sleep and severely interfering with it. The patient's movements ceased with the onset of stage 1 sleep, while in his brother, the motor activity persisted in stages 1 and 2 of sleep.
Boghen D, Peyronnard J. Myoclonus in Familial Restless Legs Syndrome. Arch Neurol. 1976;33(5):368–370. doi:10.1001/archneur.1976.00500050054010
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: