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May 1976

Myoclonus in Familial Restless Legs Syndrome

Author Affiliations

From the Neurology Section, Department of Medicine, Hôtel-Dieu Hospital, and the University of Montreal.

Arch Neurol. 1976;33(5):368-370. doi:10.1001/archneur.1976.00500050054010

• Eighteen members of a family were affected over a span of five generations with the restless legs syndrome, transmitted as an autosomal dominant trait.

Ten patients had myoclonus. The propositus, a 57-year-old man, suffered from repeated, intense, asymmetric flexion jerks of the lower extremities, alternating with fidgeting and friction movements of the legs; all occurred at night prior to sleep and severely interfering with it. The patient's movements ceased with the onset of stage 1 sleep, while in his brother, the motor activity persisted in stages 1 and 2 of sleep.