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Norris's report shows statistically that treatment with dexamethasone did not influence favorably the outcome of acute cerebral infarction in a group of patients compared to an untreated group. Two points in the paper deserve comment: (1) The treated group had, in general, greater neurologic deficits than the untreated group. Was this difference significant, and could it influence the results? (2) Using the criterion of a decrease of neurologic deficits from a score greater than 100 to a score less than 50, five patients in the treated group (No. 8, 11, 17, 19 and 20) made what might be considered to be a dramatic recovery from a severe deficit, but only one patient in the untreated group (No. 18) made such a recovery. Is it possible that certain patients with severe deficits might benefit from treatment with dexamethasone?
Many neurologists have noted apparently beneficial or unfavorable results from treatment with dexamethasone in specific patients
Waltz AG. To the Editor.—. Arch Neurol. 1976;33(5):375. doi:10.1001/archneur.1976.00500050061021
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