[Skip to Content]
[Skip to Content Landing]
October 1976

Myoclonus and Alzheimer Disease-Reply

Author Affiliations

Dept of Neurophysiology Walter Reed Army Med Center Washington, DC 20012

Arch Neurol. 1976;33(10):730. doi:10.1001/archneur.1976.00500100064024

In Reply.—  There have been at least six reports in addition to the one by Feldman et al1 that describe myoclonus in conjunction with familial Alzheimer disease. These are reviewed in Jacob's article,2 which is cited in our article. We did not include any of these references, since the article dealt specifically with "sporadic, nonfamilial" cases of Alzheimer disease, ie, those that could be confused with Creutzfeld-Jacob disease. One reference3 describing myoclonus in nonfamilial Alzheimer disease was omitted, however, and was recently brought to my attention.The familial cases described by Feldman et al also showed prominent extrapyramidal signs as well as generalized seizures. Thus, their finding of neurofibrillary tangles in the anterior horn cells in this family would seem to be of uncertain significance in implicating a spinal cord origin of the myoclonus in sporadic cases of Alzheimer disease.Since the myoclonus in Alzheimer disease has been described