[Skip to Content]
[Skip to Content Landing]
October 1976

Benzodiazepine Anticonvulsant

Author Affiliations

1039 St Paul St Baltimore, MD 21202

Arch Neurol. 1976;33(10):731. doi:10.1001/archneur.1976.00500100065026

To the Editor.—  The following sentence in Brown's article (Arch Neurol 33:326, 1976) appears to be confusing and misleading, and requires clarification: "The drug (clonazepam) is not approved by the FDA for treatment of grand mal, partial seizures with complex symptoms (psychomotor, temporal lobe), or focal seizures." This statement provoked a number of physicians to contact us as to whether or not they can "legally" prescribe clonazepam to patients with "mixed epilepsy" (petit mal and grand mal; myoclonic and grand mal). We do not believe that Dr Browne intended to advise physicians against the use of clonazepam in patients with grand mal and an "approved" type of seizure, but simply meant that the efficacy of clonazepam in the treatment of grand mal epilepsy has not been established in this country.Browne states, "... no cases of serious hematopoietic, hepatic, or renal toxicity appear to have occurred." We are cognizant of two