• An attempt was made to evaluate the potential advantages of chemotherapy in the treatment of 62 patients with glioblastoma. Twenty-four of the 62 patients received adjuvant nitrosourea chemotherapy with carmustine (BCNU), lomustine (CCNU), or semustine (methyl CCNU) in addition to surgery and radiotherapy. Thirty-three of the 62 patients were involved in a controlled, prospective, randomly allocated study. Quality or quantity of survival was not prolonged in patients who received chemotherapy. Age greater than 64 years, a severe postoperative neurological deficit, or the onset of symptoms less than 12 months prior to surgery were associated with a worse prognosis. The valid evaluation of the effect of a form of treatment on survival in patients with glioblastoma is contingent on the rigorous avoidance of preselected factors that may predispose the treated group to a more favorable prognosis.
Brisman R, Housepian EM, Chang C, Duffy P, Balis E. Adjuvant Nitrosourea Therapy for Glioblastoma. Arch Neurol. 1976;33(11):745–750. doi:10.1001/archneur.1976.00500110013003
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