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November 1976

The Effect of Acidosis in Hypokalemic Periodic Paralysis

Author Affiliations

From the Departments of Pharmacology and Therapeutics (Miss Jarrell and Dr Maren) and Neurology (Dr Greer), University of Florida College of Medicine, Gainesville.

Arch Neurol. 1976;33(11):791-793. doi:10.1001/archneur.1976.00500110059012

• Metabolic acidosis was produced in two patients with hypokalemic periodic paralysis by the administration of ammonium chloride over a period of three days. The challenging test of glucose and insulin produced a substantially smaller reduction of both serum potassium concentration and muscle strength than when the patients were tested in normal acid-base balance.

The findings agree with earlier work on acetazolamide, suggesting that metabolic acidosis provides protection against episodes of muscle weakness in periodic paralysis.

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