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November 1976

Diphasic Response to Corticosteroids in Idiopathic Relapsing Polyneuropathy

Author Affiliations

Depts of Neurology, Medicine, and Pediatrics Univ of Rochester School of Medicine and Dentistry Rochester, NY 14642
Dept of Neurology State Univ of New York Upstate Med Center Syracuse, NY 13210

Arch Neurol. 1976;33(11):794-795. doi:10.1001/archneur.1976.00500110062013

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Corticosteroid treatment has been associated with prolonged remissions in chronic idiopathic relapsing polyneuritis (IRP).1-4 Recently, it has been noted that this response may require prolonged therapy,2 but can be maintained with alternate-day corticosteroid administration.3 Some authors have not noted a beneficial effect5 or have noted a worsening with corticosteroid therapy.4.6 The possibility that an initial worsening might precede improvement has not been considered.

We have treated a man with IRP whose initial response to corticosteroids was a dramatic worsening on each of four occasions. Although this

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