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January 1977

Focal Motor Seizures

Author Affiliations

Depts of Neurology and Pharmacology UCLA School of Medicine Div of Neurology Harbor General Hospital Campus Torrance, CA 90509

Arch Neurol. 1977;34(1):57. doi:10.1001/archneur.1977.00500130077016

To the Editor.—  In their recent article in the Archives (33:536, 1976), Collins et al report that the uptake of carbon 14-labeled 2-deoxyglucose is increased in the thalamus during severe focal seizures with or without bilateral spread; they attribute the changes in their autoradiographs to increased neuronal metabolism associated with seizure spread. A number of years ago, my associates and I1 reported a study of the influence of 25% CO2 on the uptake of sulfur 35-labeled sulfate by brain and demonstrated autoradiographic changes that are very similar in appearance to those of Collins and co-workers, that is, a patchy increase in radioactivity in the thalamus of some animals. We referred in that article to still earlier studies by Lee and Olszewski2 and Rozdilsky and Olszewski3 who demonstrated a similar pattern in animals subjected to electroshock in studies using radioiodine-labeled albumin. We concluded that the changes in both studies were