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January 1977

Huntington Chorea

Author Affiliations

Dept of Neurology
Dept of Pharmacology Univ of Minnesota Med School Minneapolis, MN 55455

Arch Neurol. 1977;34(1):58-59. doi:10.1001/archneur.1977.00500130078020

To the Editor.—  In a recent article in the Archives (33:517, 1976), we read the comments by Dr Kartzinel et al concerning some statements made by us on the effect of apomorphine hydrochloride on the chorea of Huntington disease.1 The authors indicate that we propose that "hypersensitive striatal dopamine (postsynaptic) receptors may not constitute the basic disturbance of the striatal dopamine systems allegedly responsible for the chorea of Huntington Disease." As with the result observed by us with apomorphine, the findings by Dr Kartzinel and associates with bromocriptine support this interpretation. With doses of up to 40 mg/day of bromocriptine, no change in the choreiform movements of their Huntington disease patients occurred. Only higher, toxic doses aggravated the involuntary movements. Daily doses of bromocriptine of less than 40 mg induce chorea in patients with Parkinson disease2 presumably through stimulation of "hypersensitive" striatal dopamine receptors. If in Huntington disease

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