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February 1977

Acetazolamide-Induced Interference With Primidone Absorption: Case Reports and Metabolic Studies

Author Affiliations

From the Departments of Pharmacology and Toxicology (Ms Syversen and Drs Morgan and Weintraub) and Pediatrics (Dr Myers), The University of Rochester School of Medicine and Dentistry, Rochester, NY.

Arch Neurol. 1977;34(2):80-84. doi:10.1001/archneur.1977.00500140034005

• Effects of acetazolamide on primidone plasma levels were studied in three patients. Apparent interaction occurred in two patients. Primidone was not detected in the plasma when given orally with acetazolamide in one patient. In another, peak serum concentration was delayed, with corresponding delays in urinary excretion of primidone and metabolites. Plasma and urine concentrations of the two metabolites, phenylethylmalonamide and phenobarbital, were also studied.

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