• Acute brain damage—cerebrovascular or cardiovascular, traumatic or infectious—released brain-type isoenzyme of creatine kinase (BB-CK) into the circulation within a few hours in 16 of 62 patients (26%). Occurrence of BB-CK was transient in the serum. BB-CK activity was found in the peripheral blood in 13 of 23 patients with diffuse brain damage compared to three of 39 patients with a local cerebrovascular accident (P <.0005). The mortality of patients having BB-CK in their serum was 63% compared to 39% of those without BB-CK activity in their serum (P <.05).
Kaste M, Somer H, Konttinen A. Brain-Type Creatine Kinase Isoenzyme: Occurrence in Serum in Acute Cerebral Disorders. Arch Neurol. 1977;34(3):142–144. doi:10.1001/archneur.1977.00500150028004
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