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March 1977

Brain-Type Creatine Kinase Isoenzyme: Occurrence in Serum in Acute Cerebral Disorders

Author Affiliations

From the Department of Neurology, University of Helsinki (Dr Kaste), the Department of Neurology, College of Physicians and Surgeons of Columbia University, New York (Dr Somer), and Kivela Hospital, Helsinki (Dr Konttinen).

Arch Neurol. 1977;34(3):142-144. doi:10.1001/archneur.1977.00500150028004

• Acute brain damage—cerebrovascular or cardiovascular, traumatic or infectious—released brain-type isoenzyme of creatine kinase (BB-CK) into the circulation within a few hours in 16 of 62 patients (26%). Occurrence of BB-CK was transient in the serum. BB-CK activity was found in the peripheral blood in 13 of 23 patients with diffuse brain damage compared to three of 39 patients with a local cerebrovascular accident (P <.0005). The mortality of patients having BB-CK in their serum was 63% compared to 39% of those without BB-CK activity in their serum (P <.05).

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