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March 1977

Vision Loss Associated With Amantadine Hydrochloride

Author Affiliations

Jules Stein Eye Institute 800 Westwood Plaza Los Angeles, CA 90024
9201 W. Sunset Blvd Los Angeles, CA 90069
Hospital of The Good Samaritan 616 S Witmer St Los Angeles, CA 90017

Arch Neurol. 1977;34(3):199-200. doi:10.1001/archneur.1977.00500150085020

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To the Editor—  Amantadine hydrochloride (Symmetrel) has two separate and apparently unrelated clinical uses: it is most commonly used to control the tremor of Parkinson disease, and it has an antiviral action in the prevention of Asian influenza. Blurring of vision has been reported as an infrequent complication of the drug. The mechanism causing this problem is unknown.

Report of a Case.—  The patient, a 67-year-old man, was first seen in 1973 for a routine eye examination. Apart from a mild astigmatic refractive error and the normal presbyopia of his age, his findings were completely within normal limits. He was seen again in August 1975 for a superficial corneal abrasion of the right eye, which cleared spontaneously without sequelae. In September 1975, his vision was fully correctable to 20/20 in each eye, with no evidence of incipient cataracts, glaucoma, macular degeneration of the retina, or optic nerve disease.In November

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