This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Dr Holmes' letter points out the continuing dilemma in attempts to define etiological agents in Reye's syndrome; many abnormalities occur simultaneously, and causal relationships are difficult to establish. It is possible that correction of increased intracranial pressure and changes in short-chain fatty acids are interrelated as well. In fact, preliminary data from our laboratory suggest that short-chain fatty acids may produce pericapillary brain edema in experimental animals (D. A. Trauner and J. de la Torre, unpublished observations).The role of exchange transfusion in Reye's syndrome is also somewhat tenuous. The fact that short-chain fatty acid concentrations may actually be increased by this procedure suggests to us, as to Dr Holmes, that the role of transfusion in this disorder should be reevaluated.
Trauner DA, Stockard JJ, Sweetman L. EEG Correlations With Biochemical Abnormalities in Reye's Syndrome-Reply. Arch Neurol. 1977;34(5):321. doi:10.1001/archneur.1977.00500170075021
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.