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July 1977

Three-Generation Pedigree of a Möbius Syndrome Variant With Chromosome Translocation

Author Affiliations

From the Division of Pediatric Neurology (Drs Ziter and Wiser), University of Utah, College of Medicine, Salt Lake City, and the National Jewish Hospital and the Department of Biophysics (Dr Robinson), University of Colorado Medical Center, Denver.

Arch Neurol. 1977;34(7):437-442. doi:10.1001/archneur.1977.00500190071011

• We report the clinical and cytogenetic data on seven members of a family, spanning three generations, who showed congenital facial diplegia and finger contractures. Each affected member showed an identical chromosome abnormality, reciprocal translocation between chromosome 1 and 13. The concurrence of the clinical and cytogenetic defect in this family suggests a direct and possibly etiologic relationship.

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