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July 1977

Three-Generation Pedigree of a Möbius Syndrome Variant With Chromosome Translocation

Arch Neurol. 1977;34(7):437-442. doi:10.1001/archneur.1977.00500190071011

• We report the clinical and cytogenetic data on seven members of a family, spanning three generations, who showed congenital facial diplegia and finger contractures. Each affected member showed an identical chromosome abnormality, reciprocal translocation between chromosome 1 and 13. The concurrence of the clinical and cytogenetic defect in this family suggests a direct and possibly etiologic relationship.