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August 1977

Blood-to-Cerebrospinal Fluid Barrier For Cyclic Adenosine Monophosphate in Man

Author Affiliations

From the Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke (Drs Brooks and Engel), and the Endocrinology Branch, Medical Service, National Naval Medical Center (Dr Sode), Bethesda, Md.

Arch Neurol. 1977;34(8):468-469. doi:10.1001/archneur.1977.00500200028004

• A definite blood to lumbar CSF barrier for cyclic adenosine monophosphate (cAMP) exists in man under physiologic conditions. Lumbar CSF cAMP level remained unchanged, while the CSF glucose level rose significantly after a glucagon hydrochloride infusion that caused a 40-fold increase in the plasma cAMP level.