• The neurologic complications of varicella-zoster (VZ) virus infections are manifested as zoster with or without CNS involvement, encephalomyelitis, or ocular involvement. Usually the association of VZ virus in these conditions has been determined by finding VZ antibodies in the serum. In a few instances, VZ antibodies have been detected in the CSF. We report two cases of VZ virus infection followed by neurologic complications involving the CNS in which VZ antibodies were present in the CSF. These two cases underscore the need and value of determining the presence of VZ antibodies in the CSF in certain instances.