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August 1977

Stapedius Reflex Decay in Myasthenia Gravis

Author Affiliations

From the Department of Neurology (Drs Warren and Gutmann) and the Division of Otolaryngology (Audiology) (Mr Cody, Ms Flowers, Mr Segal), West Virginia University, Morgantown.

Arch Neurol. 1977;34(8):496-497. doi:10.1001/archneur.1977.00500200056011

• Stapedius reflex decay, in response to a one-minute sound stimulus of 500 Hz occurred in six patients with myasthenia gravis. This decay is analagous to the decremental response of muscle action potentials to rapid nerve stimulation. Edrophonium chloride decreases the degree of decay. This represents a useful test in the diagnosis of myasthenia gravis.