• This study links a midfacial anomaly in an 8-year-old boy, with underlying bony skull defects and abnormalities of the cerebral vasculature, with an earlier spontaneous miscarriage and the subsequent birth of a frankly anencephalic sibling. We believe that the midfacial and vascular anomalies in the second child could represent a forme fruste of anencephaly, which should alert the physician to monitor subsequent pregnancies for the complete anencephalic phenotype.
Frens DB, Ziter FA, Bray PF. Bony and Vascular Anomalies of the Head: Their Possible Relation to Anencephaly. Arch Neurol. 1977;34(8):508–510. doi:10.1001/archneur.1977.00500200068014
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