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October 1977

Isotope Localization of Infarcts in Aphasia

Author Affiliations

Patricia McCabe
From the Departments of Clinical Neurological Sciences (Dr Kertesz) and Nuclear Medicine (Dr Lesk), and the Aphasia Laboratory (Dr Kertesz and Ms McCabe), University of Western Ontario, St Joseph's Hospital, London, Ontario.

Arch Neurol. 1977;34(10):590-601. doi:10.1001/archneur.1977.00500220024004

• Radionucleide localization of infarcts producing aphasia was undertaken in 65 patients with a scan-test and onset-test interval of one month or less. The scans were traced on anatomical templates without knowledge of the aphasias. Aphasics were classified by their test scores according to taxonomic criteria, independently from localization. Scans belonging to each clinically distinct group were overlapped "blindly." The results showed distinct areas for Broca's conduction and Wernicke's aphasics along the parasylvian axis of the lateral templates. Lesions of global aphasics covered all these areas, while transcorticals were outside of them. Lesion size and severity of aphasia showed significant correlation. It is concluded that a brief systematic survey of aphasia like ours is useful in predicting the anteroposterior location and often the depth and extent of lesions.

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