• Peripheral neuropathy is a rare complication of dapsone therapy. This neuropathy appears primarily to be of the motor type, and recovery occurs on discontinuation of the drug therapy. The patient in this report developed a marked motor deficit as well as a selective marked loss of vibration sense shortly after the initiation of a relatively low dose of dapsone. Recovery was rapid on cessation of the therapy. This patient was found to be a slow acetylator of isoniazid, and therefore is probably a slow acetylator of dapsone. The possible mechanisms of the neurotoxicity of dapsone and the role of altered metabolism are discussed.
William C. Koller, Louisa K. Gehlmann, Frederick D. Malkinson, Floyd A. Davis. Dapsone-Induced Peripheral Neuropathy. Arch Neurol. 1977;34(10):644–646. doi:10.1001/archneur.1977.00500220078017