We are indeed grateful to Drs Rousseau and Franck for calling our attention to their reported experience with the neurological complications of infectious mononucleosis. As they indicate, it may well be that the disorder is more common than is generally realized—in part attributable to reliance on heterophile studies for confirmation. Certainly, use of EB virus specific diagnostic testing may give better evidence as to the exact prevalence of this disorder. However, we should like to bring to their attention the fact that neurological diseases associated with EB viral infection may have other concomitant systemic illness and/or heterophile positivity. The demonstration of EB viral infection in patients with African Burkitt's lymphoma1 and nasopharyngeal carcinoma2 has already provided evidence for the heterogeneity of EB virus-related diseases. It would appear that the possibility exists that a diverse group of neurological disorders may be associated with EB viral infection.Though we agree
Yahr MD, Friedland R. Acute Neurological Forms of Infectious Mononucleosis-Reply. Arch Neurol. 1977;34(10):651. doi:10.1001/archneur.1977.00500220085025
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