• Unilateral embolization of the brain was performed in cats by intracarotid injection of 10.5 million carbonized microspheres (15 ± 5 μ). Intracranial pressure increased from 6.1 ±1.5 to 14 ± 2.3 mm Hg within two minutes and continued to rise more slowly to 24 ± 18.3 mm Hg within four hours. Embolization caused a nonhomogenous distribution of microflow, but initially had no effect on global cerebral blood flow, nor on cortical oxygen tension. Yet, a functional suppression of cortical electrical and metabolic activity occurred. The ipsilateral EEG flattened irreversibly after 15 seconds; the contralateral EEG was transiently suppressed shortly thereafter. Arteriovenous difference of oxygen fell from 10.5 ± 0.7 to 5.3 ± 0.6 vol%, and the arteriovenous difference of glucose fell from 11.7 ± 3.9 to 2.6 ± 2.1 mg/100 ml as a consequence of reduced oxygen and glucose extraction. Subsequently, severe vasogenic brain edema, secondary ischemia, and severe functional suppression developed between two and four hours.
Vise WM, Schuier F, Hossmann K, Takagi S, Zülch KJ. Cerebral Microembolization: I. Pathophysiological Studies. Arch Neurol. 1977;34(11):660–665. doi:10.1001/archneur.1977.00500230030004
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