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December 1977

Deanol Acetamidobenzoate Treatment in Choreiform Movement Disorders

Author Affiliations

From the Department of Neurology (Drs Tarsy and Bralower), Boston Veterans Administration Hospital and Boston University School of Medicine, Boston, and the Division of Neurology (Dr Tarsy), Department of Medicine, New England Deaconess Hospital and Harvard Medical School, Boston, Mass.

Arch Neurol. 1977;34(12):756-758. doi:10.1001/archneur.1977.00500240044007

• Deanol acetamidobenzoate was administered in double-blind, crossover fashion with placebo to five patients with tardive dyskinesia, three patients with Huntington's chorea, and one patient with posthemiplegic chorea. No significant effect on dyskinesia was observed. Preliminary administration of physostigmine salicylate to patients with tardive dyskinesia had a variable effect, while benztropine mesylate produced no change. Since the status of deanol as an effective precursor of acetylcholine is uncertain, further trials with putative cholinergic agents remain warranted in choreiform syndromes.

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