• A 65-year-old man suffered a midbrain infarct after coronary artery bypass surgery. He was left with a severe neuroophthalmologic deficit consisting of paralysis of upward and downward vertical gaze, weakness of adduction of the left eye, a dilated fixed left pupil, and partial right Horner's syndrome. He died 31 months after the episode. Postmortem examination disclosed an infarct involving parts of both oculomotor nuclei as well as supranuclear structures thought to be involved in the mediation of vertical eye movements.
Reagan TJ, Trautmann JC. Combined Nuclear and Supranuclear Defects in Ocular Motility: A Clinicopathologic Study. Arch Neurol. 1978;35(3):133–137. doi:10.1001/archneur.1978.00500270015004
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.