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June 1978

Moyamoya and Hageman Factor (Factor XII) Deficiency in a Black Adult

Author Affiliations

Dept of Neurology
Dept of Medicine Medical College of Pennsylvania 3300 Henry Ave Philadelphia, PA 19129

Arch Neurol. 1978;35(6):396. doi:10.1001/archneur.1978.00500300070015

To the Editor.—  We wish to add another case of moyamoya in a black adult to the cases described by Makoyo et al (Arch Neurol 34:130, 1977).A 42-year-old, right-handed, black woman was admitted to the Hospital of the Medical College of Pennsylvania because of acute left-sided weakness. She had not been taking birth control pills. Four years earlier, the patient had experienced acute aphasia and right-sided weakness from which she recovered completely. On this present admission, cerebral angiography showed a moyamoya pattern, consisting of an extensive collateral vascular formation in both basal ganglia regions and bilateral stenosis of the terminal internal carotid arteries. Her prothrombin time was normal but the partial thromboplastin time was 69 seconds with a control time of 33 seconds. This was repeated several times and was consistently twice that of the control. Assay of the coagulation factors was normal except for a 30% activity of

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