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July 1978

Autoreactivity Between Lymphocytes and Thymus Cells in Myasthenia Gravis

Author Affiliations

From the Departments of Surgery (Dr Opelz), Neurology (Dr Keesey), and Medicine (Dr Gale), School of Medicine, University of California at Los Angeles, and the Department of Allergy and Clinical Immunology, Southern California Permanente Medical Group, Los Angeles (Dr Glovsky).

Arch Neurol. 1978;35(7):413-415. doi:10.1001/archneur.1978.00500310015003

• Thymus cell preparations from four of five myasthenia gravis patients with thymic hyperplasia and from one additional patient with thymic involution stimulated autologous peripheral blood lymphocytes. No autostimulation was observed in two patients with thymoma. Autostimulation was associated with an increase in the fraction of B lymphocytes in the thymus.