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July 1978

Antibody Response to Arboviruses: Absence of Increased Response in Amyotrophic Lateral Sclerosis and Multiple Sclerosis

Author Affiliations

From the New York State Institute for Basic Research in Mental Retardation (Dr Kascsak), New York, the Yale Arbovirus Research Unit (Dr Shope), New Haven, Conn, and St Vincent's Hospital (Drs Donnenfeld and Bartfeld), New York.

Arch Neurol. 1978;35(7):440-442. doi:10.1001/archneur.1978.00500310042008

• Complement fixation and hemagglutination inhibition tests were conducted on the serums of patients with amyotrophic lateral sclerosis and multiple sclerosis using a variety of arboviral antigens. Seventy-eight complement fixation and 15 hemagglutination-inhibition viral antigens were used representing togaviruses, orbiviruses, rhadoviruses, bunyaviruses, arenaviruses, and several ungrouped agents. The serological results did not indicate any relationship between these viruses and either amyotrophic lateral sclerosis or multiple sclerosis.

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