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September 1978

Decreased Spinal Cord cGMP in Murine (Wobbler) Spontaneous Lower Motor Neuron Degeneration

Arch Neurol. 1978;35(9):590-591. doi:10.1001/archneur.1978.00500330038007

• Of the secondary messengers, cyclic guanosine monophosphate, but not cyclic adenosine monophosphate, was reduced by 80% in the cervical spinal cord and by 56% in the cerebellum of clinically affected homozygote "wobbler" mice compared to sex- and age-matched litter-mate clinically unaffected control mice. A neurotransmitter, gamma aminobutyric acid, and high-energy intermediates, adenosine triphosphate and phosphocreatine, were not significantly different in affected or unaffected mice.