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Article
September 1978

The Lissencephaly (Agyria) Syndrome in Siblings: Computerized Tomographic and Neuropathologic Findings

Author Affiliations

From the Charity Hospital of Louisiana; the Departments of Pathology and Neurology (Dr Garcia) and Radiology (Dr Trevor), Louisiana State University School of Medicine; and the Department of Neurology, Tulane University School of Medicine (Dr Dunn), New Orleans.

Arch Neurol. 1978;35(9):608-611. doi:10.1001/archneur.1978.00500330056011
Abstract

• Two consecutive nontwin siblings had the lissencephalic syndrome. The literature of this syndrome in siblings is reviewed, and the somatic and the clinicopathologic features are delineated further. Computerized tomography is reported for the first time to our knowledge in this entity as an important, noninvasive, and possibly specific test. Diagnosis early in life is possible for adequate management of the patients and genetic counseling.

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